Since 2015, Robotic Process Automation (RPA), the software robot, imitate human behaviors to take complicated tasks is more and more popular in various industry. The current references are mainly concepts the case studies that focused on the dedicated enterprise, however, less of generalization. For the goal of stepping out and going further to find the general key factors about RPA-Business alignment, researchers will use multi-valued qualitative comparative (mvQCA) method and IT-Business alignment theory. The general factors of IT-Business alignment can also affect RPA-Business. Second, there are two ways to accelerate the RPA-business alignment and six ways to slow down RPA-business alignment from the calculation results. The positive and negative have different configurations. With this research result, other mvQCA requirements could take the most of the positive factors of RPA-Business alignment. Meanwhile, the negative factors can avoid in advance. The essence of RPA is information technology.
